Article
Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer.
British journal of cancer - 1 Jan 2022
Arai Hiroyuki, Xiao Yi, Millstein Joshua, Wang Jingyuan, Battaglin Francesca, Kawanishi Natsuko, Jayachandran Priya, Soni Shivani, Zhang Wu, Mancao Christoph, Salhia Bodour, Mumenthaler Shannon M, Parikh Aparna R, Lenz Heinz-Josef
Abstract excerpt
BACKGROUND: The TIMELESS-TIPIN complex protects the replication fork from replication stress induced by chemotherapeutic drugs. We hypothesised genetic polymorphisms of the TIMELESS-TIPIN complex may affect the response, progression-free survival (PFS), and overall survival (OS) of cytotoxic drugs in patients with metastatic colorectal cancer (mCRC). METHODS: We analysed data from the MAVERICC trial, which...
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