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Article

Immunometabolism characteristics and a potential prognostic risk model associated with TP53 mutations in breast cancer.

Frontiers in immunology - 1 Jan 2022

Jiang Mengping, Wu Xiangyan, Bao Shengnan, Wang Xi, Qu Fei, Liu Qian, Huang Xiang, Li Wei, Tang Jinhai, Yin Yongmei

Abstract excerpt

TP53, a gene with high-frequency mutations, plays an important role in breast cancer (BC) development through metabolic regulation, but the relationship between TP53 mutation and metabolism in BC remains to be explored. Our study included 1,066 BC samples from The Cancer Genome Atlas (TCGA) database, 415 BC cases from the Gene Expression Omnibus (GEO) database, and two immunotherapy cohorts. We identified 92...

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Identifiers

PMID: 35935965
DOI: 10.3389/fimmu.2022.946468
PMCID: PMC9353309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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