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Article

Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue.

PloS one - 1 Jan 2018

Sun Xuezheng, Stewart Delisha A, Sandhu Rupninder, Kirk Erin L, Pathmasiri Wimal W, McRitchie Susan L, Clark Robert F, Troester Melissa A, Sumner Susan J

Abstract excerpt

Breast carcinogenesis is a multistep process accompanied by widespread molecular and genomic alterations, both in tumor and in surrounding microenvironment. It is known that tumors have altered metabolism, but the metabolic changes in normal or cancer-adjacent, nonmalignant normal tissues and how these changes relate to alterations in gene expression and histological composition are not well understood. Normal or...

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Identifiers

PMID: 29668675
DOI: 10.1371/journal.pone.0193792
PMCID: PMC5905995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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