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Article

Liquid PRF Reduces the Inflammatory Response and Osteoclastogenesis in Murine Macrophages.

Frontiers in immunology - 1 Jan 2021

Kargarpour Zahra, Nasirzade Jila, Panahipour Layla, Miron Richard J, Gruber Reinhard

Abstract excerpt

Macrophage activation and osteoclastogenesis are hallmarks of inflammatory osteolysis and may be targeted by the local application of liquid platelet-rich fibrin (PRF). Liquid PRF is produced by a hard spin of blood in the absence of clot activators and anticoagulants, thereby generating an upper platelet-poor plasma (PPP) layer, a cell-rich buffy coat layer (BC; termed concentrated-PRF or C-PRF), and the...

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Identifiers

PMID: 33897689
DOI: 10.3389/fimmu.2021.636427
PMCID: PMC8062717

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