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Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

29 Jun 2010

Abstract excerpt

Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution analysis that nonclassically restricted CD8+ T cells are universally present, but predominate in Mtb-uninfected individuals. Interestingly, these Mtb-reactive...

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PMID: 20613858
DOI: 10.1371/journal.pbio.1000407

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