Article
CD26 as a target against fibrous formation in chronic airway rejection lesions.
Life sciences - 1 Aug 2021
Jungraithmayr Wolfgang, Yamada Yoshito, Haberecker Martina, Breuer Eva, Schuurmans Macé, Dubs Linus, Itani Saria, Janker Florian, Weder Walter, Schmitt-Opitz Isabelle, Jang Jae-Hwi
Abstract excerpt
AIMS: Chronic lung allograft dysfunction (CLAD) after lung transplantation (Tx) is the clinical result of chronic airway rejection lesions (CARL), histomorphologically described as either obliterative remodeling of small airways or alveolar fibroelastosis, or as a combination of both. We here investigated the CD26-inhibitory effect on CD26-expressing CARL. MAIN METHODS: CARL were induced by BALB/c → C57BL/6 mouse...
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