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Article

Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction

23 Apr 2021

Abstract excerpt

Abstract Transcribed nucleotide repeat expansions form detectable RNA foci in patient cells that contribute to disease pathogenesis. The most widely used method for detecting RNA foci, fluorescence in situ hybridization (FISH), is powerful but can suffer from issues related to signal above background. Here we developed a repeat-specific form of hybridization chain reaction (R-HCR) as an alternative method for...

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PMID: 33892814
DOI: 10.1186/s40478-021-01169-8

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