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Article

RAN proteins and RNA foci from antisense transcripts in <i>C9ORF72</i> ALS and frontotemporal dementia

18 Nov 2013

Abstract excerpt

The finding that a GGGGCC (G4C2) hexanucleotide repeat expansion in the chromosome 9 ORF 72 (C9ORF72) gene is a common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) links ALS/FTD to a large group of unstable microsatellite diseases. Previously, we showed that microsatellite expansion mutations can be bidirectionally transcribed and that these mutations express unexpected proteins...

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PMID: 24248382
DOI: 10.1073/pnas.1315438110

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RAN proteins and RNA foci from antisense transcripts in <i>C9ORF72</i> ALS and frontotemporal dementiaPMID 24248382Read ↗

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