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Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

19 Apr 2023

Abstract excerpt

GGGGCC (G 4 C 2 ) hexanucleotide repeat expansion in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat is bidirectionally transcribed and confers gain of toxicity. However, the underlying toxic species is debated, and it is not clear whether antisense CCCCGG (C 4 G 2 ) repeat expanded RNAs contribute to disease pathogenesis. Our...

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PMID: 37073950
DOI: 10.7554/elife.85902

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