Article
IDH1105GGT single nucleotide polymorphism improves progression free survival in patients with IDH mutated grade II and III gliomas.
Pathology, research and practice - 1 May 2021
Franceschi Enrico, Biase Dario De, Di Nunno Vincenzo, Pession Annalisa, Tosoni Alicia, Gatto Lidia, Lodi Raffaele, Tallini Giovanni, Visani Michela, Bartolini Stefania, Brandes Alba Ariela
Abstract excerpt
BACKGROUND: A synonymous single nucleotide polymorphism (SNP) is a substitution of a single base that does not modify the primary amino acid sequence but could influence protein function. In patients with brain tumors, the incidence of the silent SNP IDH 1 105GGT (rs11554137) is three times higher than the normal population. METHODS: Our aim was to investigate the prognostic role of the IDH 1 105GGT SNP. We...
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