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Article

PCSK9 genetic (rs11591147) and epigenetic (DNA methylation) modifications associated with PCSK9 expression and serum proteins in CAD patients.

The journal of gene medicine - 1 Aug 2021

Shyamala Nivas, Gundapaneni Kishore Kumar, Galimudi Rajesh Kumar, Tupurani Mohini Aiyengar, Padala Chiranjeevi, Puranam Kaushik, Kupsal Keerthi, Kummari Ramanjaneyulu, Gantala Srilatha Reddy, Nallamala Krishna Reddy, Sahu Sanjib K, Hanumanth Surekha Rani

Abstract excerpt

INTRODUCTION: Proprotein convertase subtilisin/kexin type 9 (PCSK9) genetic polymorphisms play a significant role in cholesterol homeostasis. Therefore, we aimed to investigate the association of PCSK9 genetic variations NM_174936.3:c.137G>T (R46L, rs11591147) and NM_174936.3:c.1120G>T (D374Y, rs137852912), as well as promoter DNA methylation status, with mRNA expression and circulating serum protein levels in...

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Share to Coronary Artery Disease
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PMID: 33885177
DOI: 10.1002/jgm.3346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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