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Article

Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 2009

Zhang Qing, Zhou Yan-Feng, Zhang Cheng-Zhong, Zhang Xiaohui, Lu Chafen, Springer Timothy A

Abstract excerpt

The lengths of von Willebrand factor (VWF) concatamers correlate with hemostatic potency. After secretion in plasma, length is regulated by hydrodynamic shear force-dependent unfolding of the A2 domain, which is then cleaved by a specific protease. The 1.9-A crystal structure of the A2 domain dem...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19470641
DOI: 10.1073/pnas.0903679106
PMCID: PMC2695068

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19470641-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor.PMID 19470641Read ↗

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