Association of FOXP3 rs3761548 polymorphism and its reduced expression with unexplained recurrent spontaneous abortions: A South Indian study.

doi:10.1111/aji.13431

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Article

Association of FOXP3 rs3761548 polymorphism and its reduced expression with unexplained recurrent spontaneous abortions: A South Indian study.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Sept 2021

Dirsipam Kethora, Ponnala Deepika, Madduru Dhatri, Bonu Rajeswari, Jahan Parveen

Abstract excerpt

PROBLEM: Fork Head Box Protein 3 (FOXP3) is an X-linked gene, codes for a master transcription regulatory protein that controls the development and function of immunosuppressive T regulatory (Treg) cells. They are crucial mediators of maternal foetal tolerance and successful pregnancy outcome. The aim of the study is to evaluate the association of FOXP3 rs3761548 functional polymorphism and to assess the serum...

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PMID: 33882185
DOI: 10.1111/aji.13431

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