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Article

Human forkhead box protein 3 gene variants associated with altered susceptibility to idiopathic recurrent pregnancy loss: A retrospective case-control study.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Aug 2022

Bahia Wael, Zitouni Hedia, Kanabekova Perizat, Bauyrzhanova Zhansaya, Shaimardanova Moldir, Finan Ramzi R, Aimagambetova Gulzhanat, Almawi Wassim Y

Abstract excerpt

BACKGROUND: The pathogenesis of recurrent pregnancy loss (RPL) is multifactorial and not completely elucidated. Dysregulated immunity was implicated with RPL, in which regulatory T cells (Tregs) are key. As Tregs development and function are regulated by forkhead box P3 (FOXP3) transcription factor, and as FOXP3 expression is genetically determined, a role for FOXP3 polymorphisms in RPL pathogenesis was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35452532
DOI: 10.1111/aji.13551

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