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Article

Tumor Milieu Controlled by RB Tumor Suppressor

1 Apr 2020

Abstract excerpt

The RB gene is one of the most frequently mutated genes in human cancers. Canonically, RB exerts its tumor suppressive activity through the regulation of the G1/S transition during cell cycle progression by modulating the activity of E2F transcription factors. However, aberration of the RB gene is most commonly detected in tumors when they gain more aggressive phenotypes, including metastatic activity or drug...

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PMID: 32244804
DOI: 10.3390/ijms21072450

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