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Predicting the animal hosts of coronaviruses from compositional biases of spike protein and whole genome sequences through machine learning

20 Apr 2021

Abstract excerpt

The COVID-19 pandemic has demonstrated the serious potential for novel zoonotic coronaviruses to emerge and cause major outbreaks. The immediate animal origin of the causative virus, SARS-CoV-2, remains unknown, a notoriously challenging task for emerging disease investigations. Coevolution with hosts leads to specific evolutionary signatures within viral genomes that can inform likely animal origins. We obtained...

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PMID: 33878118
DOI: 10.1371/journal.ppat.1009149

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