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Natural selection differences detected in key protein domains between non-pathogenic and pathogenic feline coronavirus phenotypes

1 Jan 2023

Abstract excerpt

Feline coronaviruses (FCoVs) commonly cause mild enteric infections in felines worldwide (termed feline enteric coronavirus [FECV]), with around 12 per cent developing into deadly feline infectious peritonitis (FIP; feline infectious peritonitis virus [FIPV]). Genomic differences between FECV and FIPV have been reported, yet the putative genotypic basis of the highly pathogenic phenotype remains unclear. Here, we...

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PMID: 37038392
DOI: 10.1093/ve/vead019

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