Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia.

doi:10.1016/j.jaci.2021.04.004

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Article

Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia.

The Journal of allergy and clinical immunology - 1 Sept 2021

Konnikova Liza, Robinson Tanya O, Owings Anna H, Shirley James F, Davis Elisabeth, Tang Ying, Wall Sarah, Li Jian, Hasan Mohammad H, Gharaibeh Raad Z, Mendoza Alvarez Lybil B, Ryan Lisa K, Doty Andria, Chovanec Jack F, O'Connell Michael P, Grunes Dianne E, Daley William P, Mayer Emeran, Chang Lin, Liu Julia, Snapper Scott B, Milner Joshua D, Glover Sarah C, Lyons Jonathan J

Abstract excerpt

BACKGROUND: Hereditary alpha-tryptasemia (HαT) is characterized by elevated basal serum tryptase due to increased copies of the TPSAB1 gene. Individuals with HαT frequently present with multisystem complaints, including anaphylaxis and seemingly functional gastrointestinal (GI) symptoms. OBJECTIVE: We sought to determine the prevalence of HαT in an irritable bowel syndrome cohort and associated immunologic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33865872
DOI: 10.1016/j.jaci.2021.04.004
PMCID: PMC9017395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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