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Article

CREB1 functional polymorphisms modulating promoter transcriptional activity are associated with type 2 diabetes mellitus risk in Chinese population.

Gene - 30 Jul 2018

Xu Yao, Song Ruhui, Long Wenlin, Guo Hui, Shi Weilin, Yuan Shiliang, Xu Geng, Zhang Tongcun

Abstract excerpt

The cAMP responsive element binding protein 1 (CREB1) is a ubiquitous transcription factor that contributes to the regulation of gluconeogenesis. The mechanisms of the CREB1 function remain largely unknown. In this study, we aimed to explore genetic variations in CREB1 promoter region and determine whether these loci affect transcriptional activity and risk on type 2 diabetes (T2D). Three polymorphisms were...

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Identifiers

PMID: 29729382
DOI: 10.1016/j.gene.2018.05.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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