Article
HLA Class I Polymorphisms Influencing Both Peptide Binding and KIR Interactions Are Associated with Remission among Children with Atopic Dermatitis: A Longitudinal Study.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2021
Margolis David J, Mitra Nandita, Kim Brian S, Duke Jamie L, Berna Ron A, Hoffstad Ole J, Wasserman Jenna R, Ferriola Deborah A, Mosbruger Tim L, Wubbenhorst Bradley S, Nathanson Kathrine L, Monos Dimitri S
Abstract excerpt
Atopic dermatitis (AD) is a disease of immune dysregulation and skin barrier dysfunction with a relapsing, remitting course and has been associated with several different genetic risk variants. HLA represent a highly variable set of genes that code for cell surface protein molecules involved in the Ag-specific immune response, including the regulation or functioning of T cells, NK cells, and APCs. The purpose of...
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