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Article

Determinants of hepatic insulin clearance - Results from a Mendelian Randomization study.

Metabolism: clinical and experimental - 1 Jun 2021

Lamprinou Apostolia, Willmann Caroline, Machann Jürgen, Schick Fritz, Eckstein Sabine S, Dalla Man Chiara, Visentin Roberto, Birkenfeld Andreas L, Peter Andreas, Stefan Norbert, Häring Hans-Ulrich, Fritsche Andreas, Heni Martin, Wagner Robert

Abstract excerpt

AIMS/HYPOTHESIS: Besides insulin resistance, type 2 diabetes associates with decreased hepatic insulin clearance (HIC). We now tested for causal relationship of HIC to liver fat accumulation or features of the metabolic syndrome. METHODS: HIC was derived from oral glucose tolerance tests with the "Oral C-peptide and Insulin Minimal Models" (n = 3311). Liver fat was quantified by magnetic resonance spectroscopy...

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Identifiers

PMID: 33862045
DOI: 10.1016/j.metabol.2021.154776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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