Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription-replication conflict regions.

PLoS genetics - 1 Apr 2021

Park Kiwon, Ryoo Jeongmin, Jeong Heena, Kim Minsu, Lee Sungwon, Hwang Sung-Yeon, Ahn Jiyoung, Kim Doyeon, Moon Hyungseok C, Baek Daehyun, Kim Kwangsoo, Park Hye Yoon, Ahn Kwangseog

Abstract excerpt

The comorbid association of autoimmune diseases with cancers has been a major obstacle to successful anti-cancer treatment. Cancer survival rate decreases significantly in patients with preexisting autoimmunity. However, to date, the molecular and cellular profiles of such comorbidities are poorly understood. We used Aicardi-Goutières syndrome (AGS) as a model autoimmune disease and explored the underlying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Autoimmune Diseases of the Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Replication

Share to Fibroblasts

Share to Genomic Instability

Share to Nervous System Malformations

Share to SAM Domain and HD Domain-Containing Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 33857133
DOI: 10.1371/journal.pgen.1009523
PMCID: PMC8078737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription-replication conflict regions.PMID 33857133Read ↗

SAMHD1 prevents autoimmunity by maintaining genome stabilitySemantic proximity Read ↗

Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).Semantic proximity Read ↗

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune responseSemantic proximity Read ↗

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNASemantic proximity Read ↗

Aicardi-Goutières Syndrome caused by SAMHD1 mutation: Pathogenesis and Beyond.Semantic proximity Read ↗

SAMHD1-deficient fibroblasts from Aicardi-Goutières Syndrome patients can escape senescence and accumulate mutations.Semantic proximity Read ↗

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damageSemantic proximity Read ↗

An Autoimmune Transcriptional Circuit Driving Foxp3 <sup>+</sup> Regulatory T cell DysfunctionSemantic proximity Read ↗

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammationSemantic proximity Read ↗

SAMHD1 Functions and Human Diseases.Semantic proximity Read ↗

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflictsSemantic proximity Read ↗

Exploring the interplay between autoimmunity and cancer to find the target therapeutic hotspots.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.