Article
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer.
Communications biology - 14 Apr 2021
Maroni Giorgia, Bassal Mahmoud A, Krishnan Indira, Fhu Chee Wai, Savova Virginia, Zilionis Rapolas, Maymi Valerie A, Pandell Nicole, Csizmadia Eva, Zhang Junyan, Storti Barbara, Castaño Julio, Panella Riccardo, Li Jia, Gustafson Corinne E, Fox Sam, Levy Rachel D, Meyerovitz Claire V, Tramontozzi Peter J, Vermilya Kimberly, De Rienzo Assunta, Crucitta Stefania, Bassères Daniela S, Weetall Marla, Branstrom Art, Giorgetti Alessandra, Ciampi Raffaele, Del Re Marzia, Danesi Romano, Bizzarri Ranieri, Yang Henry, Kocher Olivier, Klein Allon M, Welner Robert S, Bueno Raphael, Magli Maria Cristina, Clohessy John G, Ali Azhar, Tenen Daniel G, Levantini Elena
Abstract excerpt
Lung cancer is the leading cause of cancer deaths. Tumor heterogeneity, which hampers development of targeted therapies, was herein deconvoluted via single cell RNA sequencing in aggressive human adenocarcinomas (carrying Kras-mutations) and comparable murine model. We identified a tumor-specific, mutant-KRAS-associated subpopulation which is conserved in both human and murine lung cancer. We previously reported...
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