Article
A novel mutation in the FcgammaRIIIA gene (CD16) results in active natural killer cells lacking CD16.
Autoimmunity - 1 Jan 1999
Takeuchi T, Nakagawa T, Ikemoto T, Sasaki M, Makino S, Shimizu A, Ohsawa N
Abstract excerpt
We report a novel mutation in FcgammaRIIIA (the transmembrane-form CD16) on natural killer (NK) cells in a patient with polyneuropathy. She had no history of recurrent infections. Her NK cells expressed no detectable CD16; however, her NK cytotoxic activity was normal, suggesting that CD16 expression and cytotoxic activity are independent of one another. Molecular analysis revealed a deletion of a single adenine...
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