Article

Integrated germline and somatic molecular profiling to detect cancer predisposition has a high clinical impact in poor-prognosis paediatric cancer

2024-08-09

Abstract excerpt

Germline predisposition has a significant role in paediatric cancer. However, the optimal approach to identifying cancer-causing germline pathogenic variants (GPV) in children, and even the prevalence of GPV among children with cancer, remain unclear. Here we report our findings from a comprehensive survey of GPV in 496 children with poor-prognosis cancer. By integrating tumour and germline molecular profiling we...

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Literature Corpus work: 9dbcc81c-ecfb-5b66-9ee0-539e4c96805d
DOI: 10.1101/2024.08.08.24311493

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