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Article

Protective effects of a small molecule inhibitor, DDQ against amyloid beta in Alzheimer's disease.

Mitochondrion - 1 Jul 2021

Vijayan Murali, Bose Chhanda, Reddy P Hemachandra

Abstract excerpt

The purpose of our study is to determine the protective effects of the newly discovered molecule DDQ (diethyl (3,4-dihydroxyphenethylamino)(quinolin-4-yl) methylphosphonate) against mutant APP and amyloid-beta (Aβ) in Alzheimer's disease (AD). To achieve our objective, we used a well characterized amyloid-beta precursor protein (APP) transgenic mouse model (Tg2576 strain). We administered DDQ, a 20 mg/kg body...

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Identifiers

PMID: 33839321
DOI: 10.1016/j.mito.2021.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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