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Article

Prognostic impact of specific molecular profiles in pediatric acute megakaryoblastic leukemia in non-Down syndrome.

Genes, chromosomes & cancer - 1 May 2017

Hara Yusuke, Shiba Norio, Ohki Kentaro, Tabuchi Ken, Yamato Genki, Park Myoung-Ja, Tomizawa Daisuke, Kinoshita Akitoshi, Shimada Akira, Arakawa Hirokazu, Saito Akiko M, Kiyokawa Nobutaka, Tawa Akio, Horibe Keizo, Taga Takashi, Adachi Souichi, Taki Tomohiko, Hayashi Yasuhide

Abstract excerpt

Pediatric acute megakaryoblastic leukemia in non-Down syndrome (AMKL) is a unique subtype of acute myeloid leukemia (AML). Novel CBFA2T3-GLIS2 and NUP98-KDM5A fusions recurrently found in AMKL were recently reported as poor prognostic factors. However, their detailed clinical and molecular characteristics in patients treated with recent improved therapies remain uncertain. We analyzed molecular features of 44...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Megakaryoblastic, Acute

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Source

Identifiers

PMID: 28063190
DOI: 10.1002/gcc.22444

Genes

GLIS2
NUP98
EFS
RBM15
GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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