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Synthetic biology-inspired development of live attenuated influenza vaccines

27 Aug 2025

Abstract excerpt

Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns. Recent advances in rational design enable precise genetic modifications to enhance safety and immunogenicity. This review highlights key molecular strategies advancing next-generation LAIV development and their potential to accelerate the...

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PMID: 40866380
DOI: 10.1038/s41541-025-01255-1

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