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Article

Light-Activation of DNA-Methyltransferases.

Angewandte Chemie (International ed. in English) - 7 Jun 2021

Wolffgramm Jan, Buchmuller Benjamin, Palei Shubhendu, Muñoz-López Álvaro, Kanne Julian, Janning Petra, Schweiger Michal R, Summerer Daniel

Abstract excerpt

5-Methylcytosine (5mC), the central epigenetic mark of mammalian DNA, plays fundamental roles in chromatin regulation. 5mC is written onto genomes by DNA methyltransferases (DNMT), and perturbation of this process is an early event in carcinogenesis. However, studying 5mC functions is limited by the inability to control individual DNMTs with spatiotemporal resolution in vivo. We report light-control of DNMT...

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Identifiers

PMID: 33826797
DOI: 10.1002/anie.202103945
PMCID: PMC8251764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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