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Article

Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments.

Molecular systems biology - 1 Apr 2021

Chen Yu, van Pelt-KleinJan Eunice, van Olst Berdien, Douwenga Sieze, Boeren Sjef, Bachmann Herwig, Molenaar Douwe, Nielsen Jens, Teusink Bas

Abstract excerpt

Cells adapt to different conditions via gene expression that tunes metabolism for maximal fitness. Constraints on cellular proteome may limit such expression strategies and introduce trade-offs. Resource allocation under proteome constraints has explained regulatory strategies in bacteria. It is unclear, however, to what extent these constraints can predict evolutionary changes, especially for microorganisms that...

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Identifiers

PMID: 33821549
DOI: 10.15252/msb.202010093
PMCID: PMC8022198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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