Bridging substrate intake kinetics and bacterial growth phenotypes with flux balance analysis incorporating proteome allocation.

Abstract excerpt

Empirical kinetic models such as the Monod equation have been widely applied to relate the cell growth with substrate availability. The Monod equation shares a similar form with the mechanistically-based Michaelis-Menten kinetics for enzymatic processes, which has provoked long-standing and un-concluded conjectures on their relationship. In this work, we integrated proteome allocation principles into a Flux...

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