Article
Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms.
Disease models & mechanisms - 26 Mar 2018
Pansarasa Orietta, Bordoni Matteo, Drufuca Lorenzo, Diamanti Luca, Sproviero Daisy, Trotti Rosa, Bernuzzi Stefano, La Salvia Sabrina, Gagliardi Stella, Ceroni Mauro, Cereda Cristina
Abstract excerpt
In the past, amyotrophic lateral sclerosis (ALS) has been considered a 'neurocentric' disease; however, new evidence suggests that it should instead be looked at from a 'multisystemic' or 'non-neurocentric' point of view. From 2006, we focused on the study of non-neural cells: ALS patients' peripheral blood mononuclear cells (PMBCs) and lymphoblastoid cell lines (LCLs). Here, we characterize LCLs of sporadic ALS...
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