Article
Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex.
Neuroscience - 19 Nov 2016
Ramos Raddy L, Toia Alyssa R, Pasternack Daniel M, Dotzler Timothy P, Cuoco Joshua A, Esposito Anthony W, Le Megan M, Parker Alexander K, Goodman Jeffrey H, Sarkisian Matthew R
Abstract excerpt
Subcortical band heterotopia (SBH) are malformations of the human cerebral cortex typically associated with epilepsy and cognitive delay/disability. Rodent models of SBH have demonstrated strong face validity as they are accompanied by both cognitive deficits and spontaneous seizures or reduced seizure threshold. BXD29-Tlr4lps-2J/J recombinant inbred mice display striking bilateral SBH, partial callosal agenesis,...
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