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Article

Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.

Cancer cell - 1 Apr 2005

Lugthart Sanne, Cheok Meyling H, den Boer Monique L, Yang Wenjian, Holleman Amy, Cheng Cheng, Pui Ching-Hon, Relling Mary V, Janka-Schaub Gritta E, Pieters Rob, Evans William E

Abstract excerpt

Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients and used a genome-wide approach to identify 45 genes differentially expressed in ALL exhibiting crossresistance to prednisolone, vincristine,...

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Identifiers

PMID: 15837626
DOI: 10.1016/j.ccr.2005.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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