A 3' Untranslated Region Polymorphism of CTNNB1 (Rs2953) Alters MiR-3161 Binding and Affects the Risk of Ischemic Stroke and Coronary Artery Disease in Chinese Han Population.

doi:10.1159/000514543

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A 3' Untranslated Region Polymorphism of CTNNB1 (Rs2953) Alters MiR-3161 Binding and Affects the Risk of Ischemic Stroke and Coronary Artery Disease in Chinese Han Population.

European neurology - 1 Jan 2021

Zhao Xin-Yi, Hu Shu-Yan, Yang Jia-Lei, Chen Xing-Mei, Huang Xian-Li, Tang Lue-Jun, Gu Lian, Su Li

Abstract excerpt

BACKGROUND: CTNNB1 is reported to be related to the pathological process of ischemic stroke (IS) and coronary artery disease (CAD). Polymorphism located in the 3' untranslated region (3'UTR) of a gene might affect gene expression by modifying binding sites for microRNAs (miRNAs). This study aimed to analyze the association between polymorphism rs2953, which locates in the 3'UTR of CTNNB1, and the risk of IS and...

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PMID: 33789307
DOI: 10.1159/000514543

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