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A metal ion orients mRNA to ensure accurate 2’- <i>O</i> ribosyl methylation of the first nucleotide of the SARS-CoV-2 genome

2021-03-12

Abstract excerpt

The SARS-CoV-2 nsp16/nsp10 enzyme complex modifies the 2’-OH of the first transcribed nucleotide of the viral mRNA by covalently attaching a methyl group to it. The 2’- O methylation of the first nucleotide converts the status of mRNA cap from Cap-0 to Cap-1, and thus, helps the virus evade immune surveillance in the host cell. Here, we report two structures of nsp16/nsp10 representing pre- and post-release state...

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Identifiers and source

Literature Corpus work
74979859-551d-515e-831d-c6ff355c0d2a
DOI
10.1101/2021.03.12.435174
Open publication

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A metal ion orients mRNA to ensure accurate 2’- <i>O</i> ribosyl methylation of the first nucleotide of the SARS-CoV-2 genomeDOI 10.1101/2021.03.12.435174
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