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Mesenchymal stem cell‐conditioned medium attenuates the retinal pathology in amyloid‐β‐induced rat model of Alzheimer's disease: Underlying mechanisms

30 Mar 2021

Abstract excerpt

Abstract Amyloid‐beta (Aβ) oligomer is known to contribute to the pathophysiology of age‐related macular degeneration. Herein, we aimed to elucidate the in vivo and in vitro effects of Aβ 1‐42 application on retinal morphology in rats. Our in vivo studies revealed that intracerebroventricular administration of Aβ 1‐42 oligomer caused dysmorphological changes in both retinal ganglion cells and retinal pigment...

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PMID: 33783931
DOI: 10.1111/acel.13340

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