Article

Effect of Resveratrol on PI3K/Akt/GSK-3β Pathway and Metalloproteases in Differentiated and Aβ-Induced Alzheimer's Model Neuroblastoma Cells

2024-03-30

Abstract excerpt

<title>Abstract</title> <p>Purpose To analyze the expressional changes in the PI3K/Akt/GSK-3β pathway and metalloprotease in the cellular AD model with the effect of antioxidant resveratrol. Methods We obtained neuron-like cells by a two-step method of neuronal differentiation by using a combination of retinoic acid (RA) and brain-derived factor (BDNF) exposure. Then, the application of the Aβ25–35 protein (10...

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Literature Corpus work: 9caf8e52-84a6-54bf-b346-75ec6fdd06f5
DOI: 10.21203/rs.3.rs-4138036/v1

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