Article
Metformin ameliorates the severity of experimental Alport syndrome.
Scientific reports - 29 Mar 2021
Omachi Kohei, Kaseda Shota, Yokota Tsubasa, Kamura Misato, Teramoto Keisuke, Kuwazuru Jun, Kojima Haruka, Nohara Hirofumi, Koyama Kosuke, Ohtsuki Sumio, Misumi Shogo, Takeo Toru, Nakagata Naomi, Li Jian-Dong, Shuto Tsuyoshi, Suico Mary Ann, Miner Jeffrey H, Kai Hirofumi
Abstract excerpt
Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis. However, the ability of metformin to improve non-diabetic glomerular disease and chronic kidney disease (CKD) has not been explored. To investigate the effect of metformin on non-diabetic glomerular disease, we used a...
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