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Article

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma.

Nature - 1 May 2021

Cele Sandile, Gazy Inbal, Jackson Laurelle, Hwa Shi-Hsia, Tegally Houriiyah, Lustig Gila, Giandhari Jennifer, Pillay Sureshnee, Wilkinson Eduan, Naidoo Yeshnee, Karim Farina, Ganga Yashica, Khan Khadija, Bernstein Mallory, Balazs Alejandro B, Gosnell Bernadett I, Hanekom Willem, Moosa Mahomed-Yunus S, Lessells Richard J, de Oliveira Tulio, Sigal Alex

Abstract excerpt

SARS-CoV-2 variants of concern (VOC) have arisen independently at multiple locations1,2 and may reduce the efficacy of current vaccines that target the spike glycoprotein of SARS-CoV-23. Here, using a live-virus neutralization assay, we compared the neutralization of a non-VOC variant with the 501Y.V2 VOC (also known as B.1.351) using plasma collected from adults who were hospitalized with COVID-19 during the two...

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Identifiers

PMID: 33780970
DOI: 10.1038/s41586-021-03471-w
PMCID: PMC9867906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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