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Article

Emergence and impact of oprD mutations in Pseudomonas aeruginosa strains in cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jan 2022

Sherrard Laura J, Wee Bryan A, Duplancic Christine, Ramsay Kay A, Dave Keyur A, Ballard Emma, Wainwright Claire E, Grimwood Keith, Sidjabat Hanna E, Whiley David M, Beatson Scott A, Kidd Timothy J, Bell Scott C

Abstract excerpt

BACKGROUND: Antimicrobial resistance in cystic fibrosis (CF) Pseudomonas aeruginosa airway infection is complex and often attributed to chromosomal mutations. How these mutations emerge in specific strains or whether particular gene mutations are clinically informative is unclear. This study focused on oprD, which encodes an outer membrane porin associated with carbapenem resistance when it is downregulated or...

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PMID: 33775602
DOI: 10.1016/j.jcf.2021.03.007

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