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Article

Glucocorticoid receptor dimerization in the cytoplasm might be essential for nuclear localization.

Biochemical and biophysical research communications - 14 May 2021

Lee Su-Jun, Shizu Ryota, Negishi Masahiko

Abstract excerpt

The glucocorticoid receptor (GR) plays an important role in steroid-dependent regulation of metabolism, development, and the immune response in humans. Although GR is known to be activated by the binding of glucocorticoid, the mechanism of action is poorly understood. We investigated dimerization of GR in the cytoplasm and nuclear trans-localization in response to treatment with the ligand dexamethasone....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33773137
DOI: 10.1016/j.bbrc.2021.03.071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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