Article
Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking.
The Journal of clinical endocrinology and metabolism - 1 Nov 2001
Kino T, Stauber R H, Resau J H, Pavlakis G N, Chrousos G P
Abstract excerpt
The syndrome of familial or sporadic glucocorticoid resistance is characterized by hypercortisolism without the clinical stigmata of Cushing syndrome. This condition is usually caused by mutations of the human GR, a ligand-activated transcription factor that shuttles between the cytoplasm and the...
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