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Article

OncoGEMINI: software for investigating tumor variants from multiple biopsies with integrated cancer annotations.

Genome medicine - 26 Mar 2021

Nicholas Thomas J, Cormier Michael J, Huang Xiaomeng, Qiao Yi, Marth Gabor T, Quinlan Aaron R

Abstract excerpt

BACKGROUND: DNA sequencing has unveiled extensive tumor heterogeneity in several different cancer types, with many exhibiting diverse subclonal populations. Identifying and tracing mutations throughout the expansion and progression of a tumor represents a significant challenge. Furthermore, prioritizing the subset of such mutations most likely to contribute to tumor evolution or that could serve as potential...

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Identifiers

PMID: 33771218
DOI: 10.1186/s13073-021-00854-6
PMCID: PMC7995589

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