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Article

PULPO: pipeline of understanding large-scale patterns of oncogenomic signatures.

Bioinformatics (Oxford, England) - 1 Jun 2026

Portasany-Rodríguez Marta, Soria-Alcaide Gonzalo, Sánchez Elena G, Ivanova Mariya, Gómez Ana, Giménez Reyes, Lalchandani Jaanam, García-Aguilera Gonzalo, Alemán-Arteaga Silvia, Saiz-Ladera Cristina, Ramírez-Orellana Manuel, Garcia-Martinez Jorge

Abstract excerpt

SUMMARY: PULPO v1.0 is a novel; fully automated pipeline designed for the preprocess and extraction of mutational signatures from raw Optical Genome Mapping (OGM) data. Built using Snakemake and executed within an isolated, Conda-managed environment, PULPO transforms complex cytogenetic alterations, captured at ultra-high resolution, into Catalogue of somatic mutations in cancer mutational signatures (COSMIC)....

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Identifiers

PMID: 41808444
DOI: 10.1093/bioinformatics/btag118
PMCID: PMC13224964

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