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CReVIS-Seq: A highly accurate and multiplexable method for genome-wide mapping of lentiviral integration sites

14 Jan 2021

Abstract excerpt

Lentiviruses have been widely used as a means of transferring exogenous DNAs into human cells to treat various genetic diseases. Lentiviral vectors are fundamentally integrated into the host genome, but their integration sites are generally unpredictable, which may increase the uncertainty for their use in therapeutics. To determine the viral integration sites in the host genome, several PCR-based methods have...

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PMID: 33768124
DOI: 10.1016/j.omtm.2020.10.012

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