Article
PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads.
Genome biology - 6 Apr 2021
Artesi Maria, Hahaut Vincent, Cole Basiel, Lambrechts Laurens, Ashrafi Fereshteh, Marçais Ambroise, Hermine Olivier, Griebel Philip, Arsic Natasa, van der Meer Frank, Burny Arsène, Bron Dominique, Bianchi Elettra, Delvenne Philippe, Bours Vincent, Charlier Carole, Georges Michel, Vandekerckhove Linos, Van den Broeke Anne, Durkin Keith
Abstract excerpt
The integration of a viral genome into the host genome has a major impact on the trajectory of the infected cell. Integration location and variation within the associated viral genome can influence both clonal expansion and persistence of infected cells. Methods based on short-read sequencing can identify viral insertion sites, but the sequence of the viral genomes within remains unobserved. We develop PCIP-seq,...
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