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TRIM33 gene somatic mutations identified by next generation sequencing in neoplasms of patients with anti-TIF1γ positive cancer-associated dermatomyositis.

Rheumatology (Oxford, England) - 1 Dec 2021

Cordel Nadège, Derambure Céline, Coutant Sophie, Mariette Xavier, Jullien Denis, Debarbieux Sébastien, Chosidow Olivier, Meyer Alain, Bessis Didier, Joly Pascal, Mathian Alexis, Levesque Hervé, Sabourin Jean-Christophe, Tournier Isabelle, Boyer Olivier

Abstract excerpt

OBJECTIVE: To deep sequence the TRIM33 gene in tumours from patients with cancer-associated anti-TIF1γ autoantibody-positive dermatomyositis (DM) as TRIM33 somatic mutations in tumours may trigger this auto-immune disease. METHODS: Next generation sequencing of tumour DNA samples from patients with cancer-associated anti-TIF1γ autoantibody-positive DM. Fourteen tumours from 13 anti-TIF1γ autoantibody-positive DM...

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PMID: 33764396
DOI: 10.1093/rheumatology/keab260

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