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Article

Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes.

The Journal of international medical research - 1 Mar 2024

Almaani Nour, Farhan Fatima, Bani Hamad Salsabiela, Abuhawileh Eman A, Koubaitary Lana, Ahram Mamoun, Aladily Tariq N

Abstract excerpt

OBJECTIVES: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; it arises from tissue-resident memory T-cells (TRM). In the present study, we investigated potential functional genetic variations that may predispose MF development. METHODS: A case-control study was conducted using whole-exome sequencing, with a focus on genes that are essential to TRM function. RESULTS: We included 21 patients and...

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PMID: 38546260
DOI: 10.1177/03000605241239034
PMCID: PMC10981233

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