Article
TRIM28 variants and Wilms' tumour predisposition.
The Journal of pathology - 1 Jul 2021
Hol Janna A, Diets Illja J, de Krijger Ronald R, van den Heuvel-Eibrink Marry M, Jongmans Marjolijn Cj, Kuiper Roland P
Abstract excerpt
TRIM28 was recently identified as a Wilms' tumour (WT) predisposition gene, with germline pathogenic variants identified in around 1% of isolated and 8% of familial WT cases. TRIM28 variants are associated with epithelial WT, but the presence of other tumour components or anaplasia does not exclude the presence of a germline or somatic TRIM28 variant. In children with WT, TRIM28 acts as a classical tumour...
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